MYCN overexpression in 17q1qMYCN further repressed genes related to NC development (D9_2; e.g., WNT-antagonist SFRP159 and nuclear receptors NR2F1/260) and led to upregulation of MYCN targets implicated in NB (D9_1; e.g., NME1 on 17q61; Supplementary Data 9). The gene discussed is MYCN; the disease is neuroblastoma.