We first intersected the development-related gene signatures (C1-C14 from Fig. 1) with marker genes identified for the tumour cells that had been mapped to those respective clusters (from all 10 investigated samples; Fig. 7c; Supplementary Data 10) and labelled each refined signature with an asterisk to distinguish it from the original gene signature (e.g., signature C13* contained genes such as DLC1 and RORA; Fig. 7c). Here, DLC1 is linked to neoplasm.