Importantly, although eosinophils are a marker of type 2 inflammation and are often used as a marker of VAERD, we did not see a correlation between eosinophil numbers and other markers of disease, such as viral titers, CD4+ cell infiltration, ALI, or DAD, during infection at 10.5 months post-vaccination (Supplementary Fig. 7). The gene discussed is CD4; the disease is infection.