GLS and neoplasm: Specifically, we observed increased expression of GLUL and GLS in TAMs (CD68+ and CD163+), TIMs (LER+ and PLAUR+), Mono 3 (monocyte cluster 3; MNDA+ and CTSA+), osteoclasts (MMP9+ and SPP1+), and endothelial cells (GNG11+ and IFI27+) in the tumor or involved BM fractions, suggesting elevated glutamine metabolism in these cell types (Fig. 1A; Supplementary Fig. S1B).