Moreover, in the NZM/NZW lupus model, Ly6Clo monocytes, which spontaneously accumulate with age, express high levels of TLR7 protein, and administration of TLR7 agonist ligands accelerates Ly6Clo monocyte augmentation in the blood and promotes nephritis (40). The gene discussed is TLR7; the disease is systemic lupus erythematosus.