Two independent studies have recently reported that (i) XIST levels were elevated in blood leucocytes from women with SLE (59) and that (ii) transgenic expression of Xist lncRNAs in male mice can promote autoantibodies directed against Xist RNP in the context of pristane-induced lupus in a permissive genetic background (SJL/J) (60). This evidence concerns the gene RNPC3 and systemic lupus erythematosus.