Two independent studies have recently reported that (i) XIST levels were elevated in blood leucocytes from women with SLE (59) and that (ii) transgenic expression of Xist lncRNAs in male mice can promote autoantibodies directed against Xist RNP in the context of pristane-induced lupus in a permissive genetic background (SJL/J) (60). Here, XIST is linked to systemic lupus erythematosus.