The most notable feature of X-linked genes affected by Xist perturbation is the high number of genes involved in innate immune response (TLR7, TLR8, TLR13, TASL, and CXCR3), which have been reported to be associated with or to have a causative role in different autoimmune diseases (table S2). This evidence concerns the gene CXCR3 and autoimmune disease.