Increasing evidence shows that AHR and AHRR also play important context-dependent roles in cancer, potentially functioning as tumor suppressors or by dampening the antitumor immune response.12,52–54 Our study showed that AHRR may be key to maintain an anti-inflammatory phenotype and limit the antimicrobial response in eosinophils when exposed to microbial signals in the intestinal environment. Here, AHRR is linked to cancer.