In contrast, in the partial correlation analyses with adjustment for covariates, higher baseline IGF-I correlated with better baseline scores of TMT-B and Stroop test I. There is a paucity of previous human studies, but in a study of older AD patients with more advanced dementia compared with our patients, lower baseline IGF-I levels were associated with a faster decline in global cognition (MMSE) over 2 years [66]. Here, IGF1 is linked to Alzheimer disease.