Continuous ketone monitoring (CKM) in addition to glucose would provide a clear benefit for people with type 1 diabetes, as diabetic ketoacidosis (DKA) is an important and potentially life-threatening complication still occurring in 10–130 per 1000 person-years due to a variety of situations, including insufficient insulin administration due to insulin pump or pen malfunction, inadequate bolus dosing, or during sick days, high-intensity exercise, hyperemesis gravidarum, excessive alcohol intake or cannabis use [13–15]. Here, INS is linked to type 1 diabetes mellitus.