The study hypothesised that T2D-diagnosed patients in remission after customized lifestyle intervention may be able to attain a normal glycemic profile through OGTT clearance, in addition to lowering HbA1c levels and improving insulin-related factors [Homeostatic model assessments of insulin resistance (HOMA-IR) and β-cell function (HOMA-β)]. The gene discussed is INS; the disease is Insulin resistance.