In this case-control study, we analyzed the associations of eight candidate SNPs polymorphisms (IGF2 rs680, IGF2R rs416572, IGF2BP2 rs4402960, rs1470579, rs11705701, rs6777038, rs16860234, rs7651090) with GDM risk, except for rs1374910, which was excluded due to not meet with the HWE test. This evidence concerns the gene IGF2 and gestational diabetes.