Xanthine oxidase inhibitors, such as febuxostat or allopurinol, are given to patients after diagnosis to decrease their uric acid levels and prevent the formation of urate crystals in kidney, which can lead to renal failure (Kelley et al., 1967; Torres et al., 2007a; Lahaye et al., 2014). This evidence concerns the gene XDH and Renal insufficiency.