KCNK16 and Glucose intolerance: Moreover, the Kcnk16 L114P mutation resulted in greater body weight gain in B6;CD-1 females compared to the WT controls (Figure 2H) due to increased lean mass, which might reduce glucose intolerance in Kcnk16 L114P (L/P) females compared to males (Figure 2—figure supplement 3A–F).