To confirm the association of Kcnk16 L114P in causing MODY, a mouse model harboring the Kcnk16 mutation was developed in the C57BL/6J background using CRISPR/spCas9 (B6 Kcnk16 L114P; Figure 1A and Figure 1—figure supplement 1A and B). This evidence concerns the gene KCNK16 and MODY.