KCNK16 and Glucose intolerance: The onset and severity of glucose intolerance in Kcnk16 L114P mice also recapitulates the data from KCNK16 L114P MODY family probands, who were diagnosed at 11 and 15 years of age and displayed an abnormal oral GTT (blood glucose: 19 and 19.6 mM, 2 hr after 75 g oral glucose bolus, respectively).