Interestingly, we observe increased neonatal lethality in heterozygous and homozygous Kcnk16 L114P mice in the C57BL/6J (B6) and the B6;CD-1 (ICR) mixed genetic backgrounds, respectively, likely due to severe hyperglycemia and lack of glucose-stimulated insulin secretion. This evidence concerns the gene INS and Hyperglycemia.