BAP1 and cancer: BAP1 is a tumor suppressor gene that contains binding domain for BRCA1 and BARD1 (Han et al. 2021); germline mutations predispose patients to a variety of cancers including uveal and cutaneous melanoma, mesothelioma, lung adenocarcinoma, meningioma, and renal cell carcinoma (Carbone et al. 2015, 2020).