BAP1 is a tumor suppressor gene that contains binding domain for BRCA1 and BARD1 (Han et al. 2021); germline mutations predispose patients to a variety of cancers including uveal and cutaneous melanoma, mesothelioma, lung adenocarcinoma, meningioma, and renal cell carcinoma (Carbone et al. 2015, 2020). This evidence concerns the gene BARD1 and renal cell carcinoma.