To provide a comprehensive understanding of the role of FYB1 in AML, we used large databases–the CCLE database, SangerBox platform (http://sangerbox.com), and GEPIA2 tool (http://gepia2.cancer-pku.cn) to analyze the expression and correlation of FYB1 with the prognosis of AML. Here, FYB1 is linked to acute myeloid leukemia.