Interestingly, we detected downregulation of YB-1 protein in ovarian tissue of chemotherapy-induced POF rats as well as in H2O2-induced POF cell model, which was reversed after MSCs-sEVs transplantation, therefore, we strongly questioned whether MSCs-sEVs could deliver YB-1 to reverse ovarian function and the potential mechanism. This evidence concerns the gene YBX1 and premature menopause.