MCAT and hepatocellular carcinoma: For instance, Metallothionein-1G (MT-1G) facilitates sorafenib resistance in hepatocellular carcinoma (HCC) cells, while knockdown of MT-1G can deplete glutathione and induce ferroptosis in sorafenib-treated HCC cells, thus restoring sensitivity of HCC cells to sorafenib (Sun et al. 2016).