Then, GO and KEGG analysis results showed that 84 up-regulated genes in the C1 molecular subtype were significantly enriched in some cancer progressed biological processes and pathways, such as TGF-β signaling pathway, NF-κB signaling pathway (Figure 4A, 4B), in contrast, 57 down-regulated genes are enriched in the ferroptosis, adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway and so on (Figure 4C, 4D). This evidence concerns the gene TGFB1 and cancer.