Consequently, the treated mice show reduced weight gain, decreased fat mass gain, smaller adipocyte size, improved peripheral glucose uptake, and enhanced insulin sensitivity in WAT.33,34 In another study, honeybee pollen extract was used to increase eosinophils in mesenteric and epididymal adipose tissue of ob/ob mice, which develop obesity and insulin resistance due to a mutation in the leptin gene. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.