LEP and obesity due to melanocortin 4 receptor deficiency: In the state of obesity or metabolic disorders, adipocytes release more leptin, which may change the phenotype of adipose eosinophils.38,39 While IL-5 injection likely increases maturation of eosinophil precursors and their release from the bone marrow, once those mature cells enter circulation and traffic to the adipose tissue, leptin activation may skew them toward a prosurvival and proinflammatory phenotype.40–42 The influence that leptin and other adipokines have on eosinophil phenotype could also contribute to comorbidities associated with obesity.