CCND1 and neoplasm: Collagen III contributes to cell adhesion, motility, and differentiation through its interaction with integrins [28] THBS2 is associated with metastatic colorectal cancer, is shown to be expressed at higher levels in lung cancer, and participates in focal adhesion signalling pathways [[29], [30]]. CCND1 gene regulates cell cycle progression and its upregulation promotes the development of various tumours.