Another reason for increased AMH may beinsulin, and Glueck et al. [10] observed a direct correlationbetween AMH and insulin insensitivity.Obesity can cause an increase in ovarian hyperandrogenproduction by a combination of follicular membranecell stimulation and ovarian function upregulation.Additionally, obesity has been shown to increaseinsulin resistance and compensatory hyperinsulinemia,which further promotes adipogenesis whileinhibiting lipolysis. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.