According to numerous studies, periodontal patients have elevated levels of systemic inflammatory mediators than healthy controls, including higher levels of C-reactive protein (CRP), Interleukin 1 (IL-1), Interleukin 6 (IL-6), and Tumor Necrosis Factor-α (TNF-α) which is also similar to the pattern of inflammatory mediator expression in patients with migraine. Here, TNF is linked to migraine disorder.