Targeted inhibition of the JAK2/STAT3 signaling has demonstrated efficacy in curtailing TNBC cell proliferation, invasion, and migration (13), knockdown of JAK2 or STAT3 in triple-negative breast cancer cells significantly reduced cell proliferation, invasion and migration (14–21), tumor volume and distant metastasis were significantly inhibited in a mouse model of triple-negative breast cancer with conditional knockout of JAK2 or STAT3 (22–25). The gene discussed is STAT3; the disease is neoplasm.