In this study, we hypothesized that the 3'UTR of oncogenes such as HER2 will be enriched with ARE-stabilizing elements, which stabilizes their oncogenic transcript and drives tumor aggressiveness, and therefore, if we change these stable elements to destabilizing elements by motif engineering and driven by mRNA de-capping promoter DCP1A, we can control the oncogene by degrading the oncogenic transcript and protein. This evidence concerns the gene ERBB2 and neoplasm.