It has been found in the study of esophageal cancer, another epithelial cell carcinoma that the expression level of C1GALT1 was positively correlated with MUC1 O- glycosylation, and the co expression of MUC1 and C1GALT1 was negatively correlated with survival rate (26). Here, C1GALT1 is linked to esophageal cancer.