C1GALT1 and familial pancreatic carcinoma: Also in pancreatic cancer, C1GALT1 knockdown significantly inhibited cell adhesion to the extracellular matrix (ECM), which was associated with a decrease in FAK phosphorylation at Y397/Y925 as well as changes in O-glycans on integrins (including β1, αv and α5 subunits) (81).