Aberrant glycosylation of MUC1 plays a role in cancer development and progression.The effect of C1GALT1 on MUC1 glycosylation plays a role in CRC development, and cancer therapies targeting MUC1 show potential, suggesting a potential effect of C1GALT1 on MUC1 glycosylation. Here, C1GALT1 is linked to colorectal carcinoma.