RHOA and myocardial infarction: In post-MI studies, a collagen-derived peptide mimic of matrix cryptin (p1159) was found to increase cardiac fibroblast migration through activation of the RhoA pathway by the membrane receptor integrin α4, reduce adverse left ventricular remodeling, dilation, collagen deposition, fibrosis and increase local vascular networks after myocardial infarction by regulating fibrotic scar deposition, alignment and perfusion, and effectively improves cardiac systolic function (37).