Finally, in the only study using 18F-SynVesT-1 PET (corrected for partial volume effect and using cerebellum as the reference) to evaluate synaptic alterations in AD to date (64 amyloid-positive - 33 at dementia and 31 at MCI stage vs. 30 controls), authors combined functional MRI and cognitive measuring to explore the correlations between SV2A density changes and markers of brain integrity. This evidence concerns the gene SV2A and dementia.