Additionally, Zhang et al. (2019) highlighted a significant reduction in 5hmC and Tet proteins, global alterations in 5hmC distribution and the identification of DhMRs associated with Cerebral Palsy (CP)-related genes, such as Notch1, Slc16a2, Dmd and Grin2b, indicating disrupted epigenetic regulation and potential impacts on gene expression critical to CP pathogenesis. Here, NOTCH1 is linked to cerebral palsy.