Indices of inflammation [e.g., circulating levels of cytokines (e.g., interleukin-6 (IL-6) and acute phase proteins (e.g., C-reactive protein (CRP)] are elevated in individuals with depression compared to controls (14) and inflammatory biomarkers have been linked to specific aspects of depression, such as anhedonia and negative affect (15–17). This evidence concerns the gene CRP and depressive symptom measurement.