The results from the ROC curve analysis showed that DHX15, USP14, COPS3, TYK2, and RIOK had AUC values of 0.931, 0.917, 0.986, 0.903, and 0.917, respectively, for T2DM (Figure 5A) and AUC values of 0.960, 0.860, 1.0, 0.9, and 0.90, respectively, for COVID-19 (Figure 5B). The gene discussed is TYK2; the disease is COVID-19.