USP14 and type 2 diabetes mellitus: In the validation dataset, the AUC values of DHX15, USP14, COPS3, TYK2, and RIOK were 0.922, 0.781, 0.812, 0.844, and 0.984, respectively, for T2DM (Figure 5C), and 0.733, 0.687, 0.737, 0.782, and 0.632, respectively, for COVID-19 (Figure 5D).