In the validation dataset, the AUC values of DHX15, USP14, COPS3, TYK2, and RIOK were 0.922, 0.781, 0.812, 0.844, and 0.984, respectively, for T2DM (Figure 5C), and 0.733, 0.687, 0.737, 0.782, and 0.632, respectively, for COVID-19 (Figure 5D). Here, TYK2 is linked to type 2 diabetes mellitus.