As demonstrated in Table 1 and Figure 3A (scatter plot), Figure 3B (forest plot), Figure 4A (scatter plot), and Figure 4B (forest plot), no causal connection was found by the IVW analysis between Crohn’s disease (121 SNPs as IVs, Supplementary Table S4) or ulcerative colitis (86 SNPs as IVs, Supplementary Table S5) and circulating VEGF (OR 1.01, 95% CI 0.99–1.03; p = 0.339 and OR 1.02, 95% CI 0.99–1.04; p = 0.140, respectively). This evidence concerns the gene VEGFA and Crohn disease.