Peroxisome proliferator-activated receptors (PPARs) signaling pathway, a class of nuclear receptors, plays a crucial role in regulating lipid homeostasis during both development and adulthood, and disruption of PPAR signaling has been associated with diseases such as obesity and glucose intolerance (Rees et al., 2008). This evidence concerns the gene PPARA and obesity due to melanocortin 4 receptor deficiency.