FOXA2 and cardiovascular disorder: For the heart proteome, the major upregulated enriched pathways were: inflammatory processes (including coagulation cascade, complement cascade), elastic fibers, amino acid metabolism, citric acid cycle, extracellular matrix interactions, integrins, cardiovascular disease pathogenesis, urea cycle, HNF-3B/FOXA2 pathway, and metabolism of fat-soluble vitamins (Figure 4A).