CFTR and cystic fibrosis: CF mutations impair CFTR function mainly by severely disrupting protein expression and channel function in the cell membrane (Amaral and Farinha, 2013), leading to abnormal water absorption (Matsui et al., 1998), mucus secretion (Joo et al., 2002), pH regulation (Pezzulo et al., 2012), bacterial infection (Reece et al., 2021) and inflammation (Khan et al., 1995) in many epithelia-lined organs, including the lungs, intestine, liver, pancreas, sweat glands and reproductive tract (Shteinberg et al., 2021).