CFTR and cystic fibrosis: CFTR is also expressed in immune cells, such as neutrophils (Painter et al., 2006; Zhou et al., 2013), monocytes (Sorio et al., 2011; Zhang et al., 2022) and macrophages (Di et al., 2006), but it remains unclear whether CFTR dysfunction disrupts the immune response of these cells and whether this significantly contributes to the development of CF lung disease.