Hence, based on the published data and our own results, we assume that theproinflammatory microenvironment of AML cells, simulated in a three-dimensionalhigh-density cell culture in vitro, can induce cell maturationand lead to the emergence of new cell clones resistant to the cytotoxic effectof antitumor cytokine TRAIL. Here, TNFSF10 is linked to acute myeloid leukemia.