BIRC3 and acute myeloid leukemia: Previously, under in vitroconditions of the inflammatory microenvironment (a three-dimensionalhigh-density culture of THP-1 AML cells), we demonstrated the emergence ofdifferentiated macrophage-like THP-1ad clones resistant to TRAIL-induced death.In the present study, constitutive activation of proinflammatory signalingpathways, associated transcription factors, and increased expression of theanti-apoptotic BIRC3 gene were observed in TRAIL-resistantmacrophage-like THP-1ad AML cells.