EZH2 and myeloid neoplasm: A point mutation in the splicingfactor SRSF2, which is observed at high frequency in patients with acutemyeloid leukemia [103, 108], causes inclusion of a poison exon intohistone methylase EZH2 transcripts, leading to its downregulation and,consequently, to the development of myeloid neoplasms, which are normallysuppressed by EZH2 [103].