In this study, gold nanoclusters (AuNTF) co-modified with TPE (AIE segment), NACB (copper ions chelator) and FA (targeting agent) were fabricated to utilize and manipulate the overexpressed copper ions in tumor cells for effective and accurate tumor theranostics via intracellular copper plunder, copper-mediated AIE imaging, copper-induced chemodynamic therapy and copper-dependent photothermal therapy, in which the AIE imaging not only monitored the whole therapeutic process in real time, but was also used to guide the photothermal therapy for optimal therapeutic efficiency. Here, BTF3 is linked to neoplasm.