However, intriguingly, it has been demonstrated that the small molecule inhibitor SI-2, can effectively suppresses BC tumor growth in an immune intact mouse at a much lower dose, by a process that is not limited to a direct inhibition of SRC-3 in cancer cells, but instead involves systemic modulation of the immune system and shaping of the composition of infiltrating immune cells in the tumor micro environment (TME) (56). The gene discussed is NCOA3; the disease is neoplasm.