NCOA3 and cancer: However, intriguingly, it has been demonstrated that the small molecule inhibitor SI-2, can effectively suppresses BC tumor growth in an immune intact mouse at a much lower dose, by a process that is not limited to a direct inhibition of SRC-3 in cancer cells, but instead involves systemic modulation of the immune system and shaping of the composition of infiltrating immune cells in the tumor micro environment (TME) (56).