NCR2 and neoplasm: This discordant regulation between NKp30 and NKp46 by IL-2 deprivation is compatible with a recent study on the sustained expression of NKp46 but the downregulation of other activating receptors, such as NKp30, NKG2D, and NKp44, in tumor-infiltrating NK cells in diverse leukemia and tumors (49, 57, 58).