Our findings suggest that increased CD8+TEM subsets in the ARE-/- mouse ovary and uterus contributed to reproductive dysfunction in an environment of systemic autoimmunity and chronic inflammation and are consistent with reports of increased CD8+T cell subsets in women with recurring miscarriage, including the presence of CD8+CD69-CD103- subsets that retain the capacity to produce IFN-γ (100). This evidence concerns the gene IFNG and spontaneous abortion.