PRL and Infertility: Though the specific cell type targeted by ARE-/- mouse CD8+T cells in the pituitary, ovary, and uterus could not be extensively examined in this study due to the severe ARE-/- mouse infertility, the differences in fertility outcome between the ARE+/- and ARE-/- mice include the observation that ARE+/- mice had higher Prl and lower IFN-γ levels compared to the ARE-/- mice and that acute elevation of IFN-γ is sufficient to break tolerance mechanisms in the ovaries of healthy mice.