CTLA4 and neoplasm: Immune Checkpoint Inhibitors (ICIs), including anti-programmed cell death protein 1 (PD-1), anti-programmed death-ligand 1 (PD-L1), and anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), could block inhibitory signals of T cell activation to promote anti-tumor immune response (3).