Another inhibitor of the Hippo pathway, XMU-MP-1, directly inhibits the kinase activity of MST1/2, enhances YAP activity, and inhibits myocardial cell apoptosis, hypertrophy, and adverse cardiac remodeling under cardiac pressure overload, thereby preventing or delaying the occurrence of heart failure (Triastuti et al., 2019). This evidence concerns the gene YAP1 and heart failure.