MALAT1 and Myocardial fibrosis: The lncRNA MALAT1 is upregulated in a high-glucose environment and regulates YAP nuclear translocation by binding to CREB to promote myocardial fibrosis by promoting cardiac fibroblast proliferation and collagen expression, thus aggravating interstitial fibrosis and myocardial damage in diabetic cardiomyopathy (Liu et al., 2020).