Studies have shown that (Chen et al., 2020b) XiaoPi granules can reduce the expression of miR-21 gene and increase the expression of PTEN gene in gastric mucosal tissues of rats with precancerous gastric cancer, as well as reduce the expression levels of Akt and PI3K proteins and reverse the abnormal activation of PI3K/AKT signalling pathway, thereby improving the pathological state of PLGC. The gene discussed is PTEN; the disease is gastric cancer.