Mutations in the protein result in the activation of the Wnt pathway in human cancers, which promotes the process of cancer transformation (Liu et al., 2022a), Additionally, β-catenin mutation is a common cause of Wnt pathway activation in gastric cancer (Clements et al., 2002), In 2002, APC mutation and classical mutation were identified as significant pathways for gastric cancer transformation (Morin et al., 1997; McCleary et al., 2016). Here, APC is linked to gastric cancer.