In the early stage of gastritis, Analysis of signalling pathways and related molecular mechanisms in the early stage of gastritis revealed that the conversion of CSG or CNAG to CAG mainly mediated three effects, including inhibition of inflammatory response, inhibition of oxidative stress, and promotion of apoptosis of gastric mucosal cells; it involved inflammation-related pathways represented by NF-κB, TGF-B, TLR, etc., the TCM such as Coptidis Rhizoma, Scutellariae Radix were represented. This evidence concerns the gene TGFB1 and gastritis.