During the infiltration phase of the inflammatory microenvironment, the major pathways involved include TLR,NF-κB, TGFβ/Smad, Wnt/β-catenin,hedgehog, PI3K-Akt, Hippo, Notch, JAK-STAT,MAPK, etc., as the disease progresses to the stage of infiltration of the tumour microenvironment, related signalling pathways such as NF-κB, TGFβ1/Smad, Wnt/β-catenin,MAPK are involved. The gene discussed is TGFB1; the disease is neoplasm.