Chinese patent medicine (Sun et al., 2020b) Zhitong Shun Qi capsule can reduce the levels of IL-1β and IL-6 in serum and the mRNA and protein expression levels of JAK1, STAT3 and c-Myc in gastric tissue, increase the mRNA and protein expression levels of SOCS-3 in gastric mucosal tissue, which improves the pathological changes of chronic atrophic gastritis and inhibit the carcinogenic process. Here, STAT3 is linked to gastritis.