Our findings suggest that decreased serum levels of IGFBP-3 serve as an independent risk factor for T2DM-MCI, consistent with the observations of Wennberg et al., who reported a positive association between higher IGFBP-3 levels and cognition among female subjects (Wennberg et al., 2018). The gene discussed is IGFBP3; the disease is type 2 diabetes mellitus.