They are known to be involved in neuronal guidance (SEMA7A), in the regulation of neuronal interaction (BCAN and NCAN), in neurogenesis (GOLM1, ROBO1, and SLITRK5) and in amyloid pathogenesis (APLP2, RTN4R, OMG, and LINGO1). Here, LINGO1 is linked to amyloidosis.