ADA and cancer: Pu and co-workers alsoemployed the 1O2-cleavablethioketal linker in their design of a nanoimmunocomplex for sono-metaboliccheckpoint trimodal cancer therapy (Figure 10c).122 This nanoimmunocomplexfeatures all FDA-approved components, including the sonosensitizerhematoporphyrin, the checkpoint blockade inhibitor aPD-L1, the immunometabolicreprogramming enzyme adenosine deaminase (ADA), and bovine serum albumin(BSA).