And probiotics and/or prebiotics might decrease cell apoptosis, and increase cell migration during rotavirus infection, which was due that probiotics and/or prebiotics elevated antioxidant capacity, and regulated some related signaling pathways (including MAPK/ERK/JNK, SIRT1/FoxO1/Rab7) [28, 29, 31, 118, 186–188]. Here, MAPK8 is linked to Rotavirus infection.