Several pathways possessed enriched genes in specific T-cell subtypes (Supplementary Fig. 2A-B). The proportion of CD8+MAIT cells was significantly higher in responders than in non-responders, indicating that CD8+MAIT cells may be associated with the efficacy of PD-1/PD-L1 blockade in patients with NSCLC (Fig. 2D). This evidence concerns the gene PDCD1 and non-small cell lung carcinoma.