ONO-4641 (another S1P receptor modulator) stimulated the growth of CD11b + Gr-1 + (MDS) cells, decreased T cell proliferation, and lowered INF-γ secretion by CD3+ T cells (with similar characteristics to MDS cells) in the lungs of naïve mice, resulting in the lymphocytopenia [295]. Here, ITGAM is linked to myelodysplastic syndrome.