SPHK1 and cancer: Other promising anti-inflammatory and SphK1-inhibiting agents (phenols and polyphenols) capable of sensitizing cancer cells to the pro-apoptotic effects of TNF-α (and/or stimulate pro-apoptotic effects of TRAIL/DR signaling) include the flavonoid epigallocatechin gallate (EGCG) [377] and the polyphenol resveratrol [378–380].