In latest recent study on Exo-miRNAs in ascites fluid, Jiaxin et al. demonstrated that exosomal hsa‐let‐7g‐3p and hsa‐miR‐10395‐3p derived from peritoneal lavage of GC with PM positively regulates TGFβ signaling by suppressing RAPGEF3 expression, which results in tumor proliferation and IP chemotherapy resistance21. This evidence concerns the gene RAPGEF3 and neoplasm.