CEACAM5 and colorectal carcinoma: In the high CEA level group, HCY levels could still effectively differentiate the RFS (32.5% vs. 50.7%, p < 0.001) and OS (33.8% vs. 53.5%, p < 0.001) of CRC patients and had a better differentiating effect than in the normal CEA level group (Supplementary Fig. S6A,B).