GPX4 and cancer: For example, Jiang et al. in a recently established ferroptosis-mediated cancer cell death using erastin, rapamycin and Fe2+ based micelle [39], while in another study by Tang and team, sorafenib-loaded manganese oxide nanoparticle depleted the GSH consumption and inactivated GPX4 causing intracellular elevation of lipid peroxide and finally death of hepatocellular carcinoma cells by ferroptosis [22].