Except for TFR1, levels of proteins involved in iron trafficking in various malignancies are a topic of debate related to cancerous and non-cancerous cells [57, 58]. An overexpression of TFR1 has been frequently observed in the tissues and cancer cells from leukemia, glioma, ovarian, prostate, breast, liver and colorectal malignancies. The gene discussed is TFRC; the disease is cancer.